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Article

The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.

Developmental cell - 1 Nov 2004

Hamada Fumihiko, Bienz Mariann

Abstract excerpt

Adenomatous polyposis coli (APC) is an important tumor suppressor in the colon. APC antagonizes the transcriptional activity of the Wnt effector beta-catenin by promoting its nuclear export and its proteasomal destruction in the cytoplasm. Here, we show that a third function of APC in antagonizin...

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Source

Identifiers

PMID: 15525529
DOI: 10.1016/j.devcel.2004.08.022

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15525529-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.PMID 15525529Read ↗

APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.Semantic proximity Read ↗

Identification of c-MYC as a target of the APC pathway.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.Semantic proximity Read ↗

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.Semantic proximity Read ↗

Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases.Semantic proximity Read ↗

The APC tumour suppressor has a nuclear export function.Semantic proximity Read ↗

Wnt signaling and colon carcinogenesis: Beyond APCSemantic proximity Read ↗

Identification of β-catenin binding regions in colon cancer cells using ChIP-SeqSemantic proximity Read ↗

Association of the APC Tumor Suppressor Protein with CateninsSemantic proximity Read ↗

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Semantic proximity Read ↗

TCF transcription factors: molecular switches in carcinogenesis.Semantic proximity Read ↗

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