Article
The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
Molecular medicine today - 1 Dec 2000
Sieber O M, Tomlinson I P, Lamlum H
Abstract excerpt
Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently, has been shown to bind DNA, suggesting that it may possess a nuclear role. The mutation spectrum implicated in...
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