Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.

Science (New York, N.Y.) - 21 Mar 1997

Morin P J, Sparks A B, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler K W

Abstract excerpt

Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical activities associated with the APC protein is down-regulation of transcriptional activation mediated by beta-catenin and T cell transcription factor 4 (Tcf-4). The pro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Neoplastic
Share to Mutation
Share to Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Signal Transduction

Share to Transcription Factors

Share to Transcription, Genetic

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9065402
DOI: 10.1126/science.275.5307.1787

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9065402-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.PMID 9065402Read ↗

Identification of c-MYC as a target of the APC pathway.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Biology of the adenomatous polyposis coli tumor suppressor.Semantic proximity Read ↗

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.Semantic proximity Read ↗

The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.Semantic proximity Read ↗

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.Semantic proximity Read ↗

Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells.Semantic proximity Read ↗

E-cadherin can limit the transforming properties of activating β-catenin mutations.Semantic proximity Read ↗

Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.Semantic proximity Read ↗

Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.Semantic proximity Read ↗

Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis.Semantic proximity Read ↗

Alpha-catenin is essential in intestinal adenoma formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.