Article
Characterization of human TCR Vbeta gene promoter. Role of the dodecamer motif in promoter activity.
The Journal of biological chemistry - 11 Sept 1998
Deng X, Sun G R, Zheng Q, Li Y
Abstract excerpt
During T-lymphocyte development, the T-cell antigen receptor (TCR) gene expression is controlled by its promoter and enhancer elements and regulated in tissue- and development stage-specific manner. To uncover the promoter function and to define positive and negative regulatory elements in TCR ge...
Topics
- Alleles
- Base Sequence
- Cells, Cultured
- Consensus Sequence
- DNA Primers
- Humans
- Jurkat Cells
- Luciferases
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Receptors, Antigen, T-Cell, alpha-beta
- Recombinant Fusion Proteins
- Regulatory Sequences, Nucleic Acid
- Sequence Alignment
- Sequence Deletion
- Sequence Homology, Nucleic Acid