Article
Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene
1 Sept 2000
Abstract excerpt
High levels of transcription from the amyloid precursor protein promoter are dependent on the binding of CTCF to the APBbeta core recognition sequence located between positions -82 and -93 upstream from the transcriptional start site. CTCF comprises 727 amino acids and contains 11 zinc finger motifs arranged in tandem that are flanked by 267 amino acids on the N-terminal side and 150 amino acids on the C-terminal...
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