Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.

Nature - 1 Jan 2000

Wirth T, Staudt L, Baltimore D

Abstract excerpt

The octamer sequence ATGCAAAT or its inverse complement ATTTGCAT is well-conserved in all immunoglobulin gene promoters and has been implicated in promoter function by deletion analysis. Although immunoglobulin promoters are tissue-specific, the octamer is also a functional element in non-tissue-specific upstream regions--like those controlling U1 and U2 small nuclear RNA and histone H2B genes--where it is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocytes

Share to Mutation

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 3627254
DOI: 10.1038/329174a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.PMID 3627254Read ↗

Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation.Semantic proximity Read ↗

Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function.Semantic proximity Read ↗

An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexes.Semantic proximity Read ↗

Transcriptional activation by simian virus 40 large T antigen: requirements for simple promoter structures containing either TATA or initiator elements with variable upstream factor binding sitesSemantic proximity Read ↗

Characterization of Transcription from TATA-Less Promoters: Identification of a New Core Promoter Element XCPE2 and Analysis of Factor RequirementsSemantic proximity Read ↗

Major histocompatibility complex class I core promoter elements are not essential for transcription in vivo.Semantic proximity Read ↗

Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates.Semantic proximity Read ↗

Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells.Semantic proximity Read ↗

A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Semantic proximity Read ↗

Mechanisms of mu enhancer regulation in B lymphocytes.Semantic proximity Read ↗

Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.Semantic proximity Read ↗

A variant octamer motif in a Xenopus H2B histone gene promoter is not required for transcription in frog oocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.