An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.

doi:10.1038/329174a0

Back to search

Article

An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity.

Nature - 1 Jan 2000

Wirth T, Staudt L, Baltimore D

Abstract excerpt

The octamer sequence ATGCAAAT or its inverse complement ATTTGCAT is well-conserved in all immunoglobulin gene promoters and has been implicated in promoter function by deletion analysis. Although immunoglobulin promoters are tissue-specific, the octamer is also a functional element in non-tissue-...

Topics

Animals
Base Sequence
Cell Line
Cells, Cultured
Genes
Globins
Lymphocytes
Mice
Mutation
Oligonucleotides
Plasmacytoma
Promoter Regions, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.