Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements.

Abstract excerpt

Transcription of human T-cell receptor (TCR) alpha genes is regulated by a T-cell-specific transcriptional enhancer that is located 4.5 kilobases 3' of the C alpha gene segment. Previous studies have demonstrated that this enhancer contains at least five nuclear protein-binding sites called T alp...

Topics

• Base Sequence
• Blotting, Southern
• Cell Line
• Chloramphenicol O-Acetyltransferase
• Chromosome Deletion
• DNA
• Enhancer Elements, Genetic
• Gene Expression Regulation
• Humans
• Molecular Sequence Data
• Mutation