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Article

Naproxen inhibits spontaneous lung adenocarcinoma formation in KrasG12V mice.

Neoplasia (New York, N.Y.) - 1 Jun 2021

Kumar Gaurav, Madka Venkateshwar, Singh Anil, Farooqui Mudassir, Stratton Nicole, Lightfoot Stanley, Mohammed Altaf, Rao Chinthalapally V

Abstract excerpt

Lung cancer is the leading cause of cancer related deaths worldwide. The present study investigated the effects of naproxen (NSAID) on lung adenocarcinoma in spontaneous lung cancer mouse model. Six-week-old transgenic KrasG12V mice (n = 20; male + female) were fed modified AIN-76A diets containing naproxen (0/400 ppm) for 30 wk and euthanized at 36 wk of age. Lungs were evaluated for tumor incidence,...

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Identifiers

PMID: 34091121
DOI: 10.1016/j.neo.2021.05.010
PMCID: PMC8187931

Genes

CXCR4
PCNA

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