Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G&gt;A Promoter Variant (rs659366)

doi:10.1155/2011/340241

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Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)

1 Jan 2011

Abstract excerpt

Uncoupling proteins (UCPs) are mitochondrial proteins able to dissipate the proton gradient of the inner mitochondrial membrane when activated. This decreases ATP-generation through oxidation of fuels and may theoretically decrease energy expenditure leading to obesity. Evidence from Ucp((-/-)) mice revealed a role of UCP2 in the pancreatic β-cell, because β-cells without UCP2 had increased glucose-stimulated...

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PMID: 21603268
DOI: 10.1155/2011/340241

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Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G&gt;A Promoter Variant (rs659366)

Abstract excerpt

Topics

Genetic Variance in<i>Uncoupling Protein 2</i>in Relation to Obesity, Type 2 Diabetes, and Related Metabolic Traits: Focus on the Functional −866G>A Promoter Variant (rs659366)