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Article

Lack of association between UCP2 gene polymorphisms and obesity phenotype in Italian Caucasians.

Journal of endocrinological investigation - 1 Oct 2003

Maestrini S, Podestà F, Di Blasio A M, Savia G, Brunani A, Tagliaferri A, Mencarelli M, Chiodini I, Liuzzi A

Abstract excerpt

The importance of the genetic component on adipose tissue accumulation has been clearly demonstrated. Among the candidate genes investigated, there are those that regulate thermogenesis and, thus, can affect energy expenditure. The uncoupling proteins (UCPs) are a family of proteins that uncouple respiration leading to generation of heat and increased energy expenditure. Contradictory data indicate that allelic...

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Source

Identifiers

PMID: 14759071
DOI: 10.1007/BF03348196

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of association between UCP2 gene polymorphisms and obesity phenotype in Italian Caucasians.PMID 14759071Read ↗

No evidence for involvement of the promoter polymorphism -866 G/A of the UCP2 gene in childhood-onset obesity in humans.Semantic proximity Read ↗

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The frequent UCP2 -866G>A polymorphism protects against insulin resistance and is associated with obesity: a study of obesity and related metabolic traits among 17 636 Danes.Semantic proximity Read ↗

Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population.Semantic proximity Read ↗

Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians.Semantic proximity Read ↗

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians.Semantic proximity Read ↗

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Mutational analysis of the UCP2 core promoter and relationships of variants with obesity.Semantic proximity Read ↗

Unleash the Association of Mitochondrial Uncoupling Protein (UCP2) Promoter Variant (G-866A; rs659366) with Obesity: Stepping from a Case-Control Study to a Meta-analysis.Semantic proximity Read ↗

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No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure.Semantic proximity Read ↗

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