Article
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians.
Human molecular genetics - 1 Sept 1998
Walder K, Norman R A, Hanson R L, Schrauwen P, Neverova M, Jenkinson C P, Easlick J, Warden C H, Pecqueur C, Raimbault S, Ricquier D, Silver M H, Shuldiner A R, Solanes G, Lowell B B, Chung W K, Leibel R L, Pratley R, Ravussin E
Abstract excerpt
The UCP2-UCP3 gene cluster maps to chromosome 11q13 in humans, and polymorphisms in these genes may contribute to obesity through effects on energy metabolism. DNA sequencing of UCP2 and UCP3 revealed three polymorphisms informative for association studies: an Ala-->Val substitution in exon 4 of UCP2, a 45 bp insertion/deletion in the 3'-untranslated region of exon 8 of UCP2 and a C-->T silent polymorphism in...
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