Article
The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules.
International immunology - 1 Aug 1998
Quarsten H, Paulsen G, Johansen B H, Thorpe C J, Holm A, Buus S, Sollid L M
Abstract excerpt
Susceptibility and resistance to type 1 diabetes are associated with MHC class II alleles that carry non-Asp and Asp at residue 57 of their beta chain respectively. The effect of Asp or non-Aspbeta57 may relate to a differential ability of distinct class II molecules to bind specific immuno-patho...
Topics
- Alanine
- Alleles
- Aspartic Acid
- B-Lymphocytes
- Binding Sites
- Cell Line
- Computer Simulation
- Diabetes Mellitus, Type 1
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- Histocompatibility Antigens Class II
- Humans
- Models, Molecular