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Article

Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004

Siebold Christian, Hansen Bjarke E, Wyer Jessica R, Harlos Karl, Esnouf Robert E, Svejgaard Arne, Bell John I, Strominger Jack L, Jones E Yvonne, Fugger Lars

Abstract excerpt

The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differential disease associations highlight a previously unrecognized interplay between the volume of the P6 pocket and the...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14769912
DOI: 10.1073/pnas.0308458100
PMCID: PMC357041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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