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Article

A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins.

Chemistry & biology - 1 Oct 2004

Zavala-Ruiz Zarixia, Strug Iwona, Anderson Matthew W, Gorski Jack, Stern Lawrence J

Abstract excerpt

Peptides bind to class II major histocompatibility complex (MHC) proteins in an extended conformation. Pockets in the peptide binding site spaced to accommodate peptide side chains at the P1, P4, P6, and P9 positions have been previously characterized and help to explain the obtained peptide binding specificity. However, two peptides differing only at P10 have significantly different binding affinities for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15489166
DOI: 10.1016/j.chembiol.2004.08.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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