Article
A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes.
Biology direct - 14 Oct 2008
Parry Christian S, Brooks Bernard R
Abstract excerpt
BACKGROUND: The mechanism underlying autoimmune diabetes has been difficult to define. There is a strong genetic contribution and numerous studies associate the major histocompatibility complex, especially the class II region, with predisposition or resistance. However, how these molecules are implicated remains obscure. PRESENTATION OF THE HYPOTHESIS: We have supplemented structural analysis with computational...
Topics
- Alleles
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Cluster Analysis
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- HLA-DQ Antigens
- HLA-DR Antigens
- Hydrogen Bonding
- Immunity, Innate
- Insulin
- Mice
- Models, Genetic
- Models, Immunological