Article
Selection of bacteriophage T4 antimutator DNA polymerases: a link between proofreading and sensitivity to phosphonoacetic acid.
Mutation research - 19 Feb 1996
Reha-Krantz L J, Wong C
Abstract excerpt
During DNA replication, DNA polymerases alternate between DNA synthesis and proofreading the newly synthesized DNA. In order to understand the molecular details of how DNA polymerases determine the balance between polymerase and proofreading activities, it would be useful to have mutants which sw...
Topics
- Amino Acids
- Bacteriophage T4
- Conserved Sequence
- DNA Replication
- DNA-Directed DNA Polymerase
- Enzyme Inhibitors
- Mutagenesis
- Nucleic Acid Conformation
- Nucleic Acid Synthesis Inhibitors
- Nucleotides
- Phenotype
- Phosphonoacetic Acid
- Suppression, Genetic
- Temperature
- Viral Proteins