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Article

Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid.

Virology - 1 Sept 1998

Staschke K A, Hatch S D, Tang J C, Hornback W J, Munroe J E, Colacino J M, Muesing M A

Abstract excerpt

Entry of influenza virus into the host cell is dependent on the fusion of the viral envelope with the endosomal membrane and is mediated by a low-pH-induced change of the viral hemagglutinin (HA) to a conformation that is fusogenic. A compound related to podocarpic acid (180299) was identified that inhibits multicycle replication of influenza A/Kawasaki/86 (H1N1) virus in culture. Treatment of Madin-Darby canine...

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Identifiers

PMID: 9721235
DOI: 10.1006/viro.1998.9273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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