Article
Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid.
Virology - 1 Sept 1998
Staschke K A, Hatch S D, Tang J C, Hornback W J, Munroe J E, Colacino J M, Muesing M A
Abstract excerpt
Entry of influenza virus into the host cell is dependent on the fusion of the viral envelope with the endosomal membrane and is mediated by a low-pH-induced change of the viral hemagglutinin (HA) to a conformation that is fusogenic. A compound related to podocarpic acid (180299) was identified th...
Topics
- Abietanes
- Amino Acid Sequence
- Animals
- Antiviral Agents
- Cells, Cultured
- Dogs
- Drug Resistance, Microbial
- Erythrocytes
- Hemagglutinins, Viral
- Humans
- Hydrogen-Ion Concentration
- Membrane Fusion
- Mutation
- Orthomyxoviridae
- Phenanthrenes
- Protein Conformation
- Virus Assembly
- Virus Replication