Article
Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics.
Journal of virology - 16 Dec 2015
Lai Kin Kui, Cheung Nam Nam, Yang Fang, Dai Jun, Liu Li, Chen Zhiwei, Sze Kong Hung, Chen Honglin, Yuen Kwok-Yung, Kao Richard Yi Tsun
Abstract excerpt
UNLABELLED: A previous screening of more than 50,000 compounds led to the identification of a pool of bioactive small molecules with inhibitory effect on the influenza A virus. One of these compounds, now widely known as nucleozin, is a small molecule that targets the influenza A virus nucleoprotein. Here we identify and characterize two structurally different novel fusion inhibitors of the influenza A virus...
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