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Article

Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.

Antimicrobial agents and chemotherapy - 1 Dec 1998

Tai C Y, Escarpe P A, Sidwell R W, Williams M A, Lew W, Wu H, Kim C U, Mendel D B

Abstract excerpt

An oral prodrug of GS 4071, a potent and selective inhibitor of influenza neuraminidases, is currently under clinical development for the treatment and prophylaxis of influenza virus infections in humans. To investigate the potential development of resistance during the clinical use of this compound, variants of the human influenza A/Victoria/3/75 (H3N2) virus with reduced susceptibility to the neuraminidase...

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Identifiers

PMID: 9835519
DOI: 10.1128/AAC.42.12.3234
PMCID: PMC106027

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