Article
Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.
Antimicrobial agents and chemotherapy - 1 Dec 1998
Tai C Y, Escarpe P A, Sidwell R W, Williams M A, Lew W, Wu H, Kim C U, Mendel D B
Abstract excerpt
An oral prodrug of GS 4071, a potent and selective inhibitor of influenza neuraminidases, is currently under clinical development for the treatment and prophylaxis of influenza virus infections in humans. To investigate the potential development of resistance during the clinical use of this compo...
Topics
- Acetamides
- Animals
- Antiviral Agents
- Cell Line
- Chick Embryo
- Dogs
- Drug Resistance, Microbial
- Enzyme Inhibitors
- Female
- Hemagglutinins
- Influenza A virus
- Kidney
- Mice
- Mice, Inbred BALB C
- Mutation
- Neuraminidase
- Oseltamivir
- Viral Plaque Assay