Article
Selection of influenza virus resistant to the novel camphor-based antiviral camphecene results in loss of pathogenicity.
Virology - 1 Nov 2018
Zarubaev Vladimir V, Pushkina Ekaterina A, Borisevich Sophia S, Galochkina Anastasia V, Garshinina Angelica V, Shtro Anna A, Egorova Anna A, Sokolova Anastasia S, Khursan Sergey L, Yarovaya Olga I, Salakhutdinov Nariman F
Abstract excerpt
Due to the ability of influenza virus to develop drug resistance, the search for novel antivirals is an important goal of medical science and health care systems. We assessed the ability of the influenza virus to develop resistance to the hemagglutinin inhibitor camphecene and characterized laboratory-selected resistant strains. We showed by electron microscopy that camphecene decreases the number of virions...
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