Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion.

Journal of medicinal chemistry - 11 Jan 2018

Leiva Rosana, Barniol-Xicota Marta, Codony Sandra, Ginex Tiziana, Vanderlinden Evelien, Montes Marta, Caffrey Michael, Luque F Javier, Naesens Lieve, Vázquez Santiago

Abstract excerpt

Two series of easily accessible anilines were identified as inhibitors of influenza A virus subtype H1N1, and extensive chemical synthesis and analysis of the structure-activity relationship were performed. The compounds were shown to interfere with low pH-induced membrane fusion mediated by the H1 and H5 (group 1) hemagglutinin (HA) subtypes. A combination of virus resistance, HA interaction, and molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aniline Compounds
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H1N1 Subtype

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Protein Conformation

Share to Virus Internalization

Source

Identifiers

PMID: 29220568
DOI: 10.1021/acs.jmedchem.7b00908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion.PMID 29220568Read ↗

Identification of Novel Fusion Inhibitors of Influenza A Virus by Chemical Genetics.Semantic proximity Read ↗

Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutininSemantic proximity Read ↗

An induced pocket for the binding of potent fusion inhibitor CL-385319 with H5N1 influenza virus hemagglutinin.Semantic proximity Read ↗

Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus.Semantic proximity Read ↗

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus.Semantic proximity Read ↗

Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening.Semantic proximity Read ↗

Potent peptidic fusion inhibitors of influenza virusSemantic proximity Read ↗

Potent Anti-Influenza Synergistic Activity of Theobromine and ArainosineSemantic proximity Read ↗

Influenza neuraminidase: A druggable target for natural productsSemantic proximity Read ↗

Identification of neuraminidase inhibitors against dual H274Y/I222R mutant strains.Semantic proximity Read ↗

Novel Neuraminidase Inhibitors: Identification, Biological Evaluation and Investigations of the Binding ModeSemantic proximity Read ↗

Peramivir binding affinity with influenza A neuraminidase and research on its mutations using an induced-fit docking approach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.