Article
Mapping mutations in influenza A virus resistant to norakin.
FEBS letters - 2 Jul 1990
Prösch S, Heider H, Schroeder C, Shilov A A, Sinitzyn B V, Blinov V M, Krüger D H, Frömmel C
Abstract excerpt
To elucidate the mode of action of norakin against influenza A virus we sequenced the hemagglutinin gene of 11 norakin-resistant mutants. Resistance was coupled with 1-3 amino acid exchanges. The majority of mutations was localized in the HA2 polypeptide and was mostly associated with changes in...
Topics
- Amino Acids
- Animals
- Antiviral Agents
- Chick Embryo
- Chromosome Mapping
- Drug Resistance, Microbial
- Hemagglutinins
- Influenza A virus
- Mutation
- Piperidines
- Protein Conformation
- RNA, Viral