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Article

Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.

Journal of virology - 1 May 1997

Gubareva L V, Robinson M J, Bethell R C, Webster R G

Abstract excerpt

Here we report the isolation of influenza virus A/turkey/Minnesota/833/80 (H4N2) with a mutation at the catalytic residue of the neuraminidase (NA) active site, rendering it resistant to the novel NA inhibitor 4-guanidino-Neu5Ac2en (GG167). The resistance of the mutant stems from replacement of one of three invariant arginines (Arg 292-->Lys) that are conserved among all viral and bacterial NAs and participate in...

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Identifiers

PMID: 9094607
DOI: 10.1128/JVI.71.5.3385-3390.1997
PMCID: PMC191482

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