Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.

doi:10.1128/JVI.71.5.3385-3390.1997

Article

Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.

Journal of virology - 1 May 1997

Gubareva L V, Robinson M J, Bethell R C, Webster R G

Abstract excerpt

Here we report the isolation of influenza virus A/turkey/Minnesota/833/80 (H4N2) with a mutation at the catalytic residue of the neuraminidase (NA) active site, rendering it resistant to the novel NA inhibitor 4-guanidino-Neu5Ac2en (GG167). The resistance of the mutant stems from replacement of o...

Topics

Animals
Antiviral Agents
Binding Sites
Cell Line
Chick Embryo
Dogs
Drug Resistance
Enzyme Inhibitors
Female
Guanidines
Influenza A virus
Mice
Mice, Inbred BALB C
Mutation
Neuraminidase
Pyrans
Sialic Acids
Virus Replication

Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en.

Abstract excerpt

Topics

Discuss the evidence