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Article

pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.

Aging cell - 1 Dec 2011

Monje José M, Brokate-Llanos Ana M, Pérez-Jiménez Mercedes M, Fidalgo Manuel A, Muñoz Manuel J

Abstract excerpt

In Caenorhabditis elegans, the insulin/IGF pathway participates in the decision to initiate dauer development. Dauer is a diapause stage that is triggered by environmental stresses, such as a lack of nutrients. Insulin/IGF receptor mutants arrest constitutively in dauer, an effect that can be suppressed by mutations in other elements of the insulin/IGF pathway or by a reduction in the activity of the nuclear...

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PMID: 21933341
DOI: 10.1111/j.1474-9726.2011.00747.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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