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Article

Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates.

Frontiers in immunology - 1 Jan 2025

Pena-Amelunxen Glorismer, Asghari Mohadeseh, Khatri Kriti, Glesner Jill, Versteeg Serge A, van Ree Ronald, Chapman Martin D, Smith Scott A, Chruszcz Maksymilian, Pomés Anna, Aglas Lorenz

Abstract excerpt

Background: Advancements in hybridoma technology have enabled the production of human IgE monoclonal antibodies (hIgE mAb) for successful IgE epitope mapping of major allergens. Here, we assessed the hypoallergenicity of three IgE-epitope mutants (single 4C8 or 2F10, and double 4C8 + 2F10 epitope mutants) of house dust mite allergen (HDM) Der p 2. Methods: Humanized rat basophilic leukemia (huRBL) cells,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 40655157
DOI: 10.3389/fimmu.2025.1623920
PMCID: PMC12246809

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