Article
The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994
Fujiwara H, Kikutani H, Suematsu S, Naka T, Yoshida K, Yoshida K, Tanaka T, Suemura M, Matsumoto N, Kojima S
Abstract excerpt
The CD23 antigen, a low-affinity receptor for IgE (Fc epsilon RII), is a type II membrane-bound glycoprotein expressed on various cells, particularly mature B cells. A number of functions have been ascribed to CD23, including specific regulation of IgE production, IgE-mediated cytotoxicity and release of mediators, IgE-dependent antigen focusing, promotion of B-cell growth, prevention of germinal center B cells...
Topics
- Animals
- Antibody Formation
- B-Lymphocytes
- Cell Differentiation
- Cell Division
- Enzyme-Linked Immunosorbent Assay
- Immunoglobulin E
- Immunophenotyping
- Mice
- Microscopy, Fluorescence