Article
Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2000
Chen Z, Koralov S B, Gendelman M, Carroll M C, Kelsoe G
Abstract excerpt
Deficiency in CD21/CD35 by disruption of the Cr2 loci leads to impaired humoral immune responses. In this study, we detail the role of CD21/CD35 on Ab responses to the hapten (4-hydroxy-3-nitrophenyl)acetyl conjugated to chicken gamma-globulin. Surprisingly, Cr2-/- mice generate significant Ab responses and germinal center (GC) reactions to low doses of this Ag in alum, although the magnitude of their responses...
Topics
- Amino Acid Sequence
- Animals
- Antibody Affinity
- Antibody-Producing Cells
- Base Sequence
- Binding Sites, Antibody
- Bone Marrow Cells
- Chickens
- Dose-Response Relationship, Immunologic
- Female
- Germinal Center
- Immunoglobulin G
- Immunoglobulin M