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Article

Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2000

Chen Z, Koralov S B, Gendelman M, Carroll M C, Kelsoe G

Abstract excerpt

Deficiency in CD21/CD35 by disruption of the Cr2 loci leads to impaired humoral immune responses. In this study, we detail the role of CD21/CD35 on Ab responses to the hapten (4-hydroxy-3-nitrophenyl)acetyl conjugated to chicken gamma-globulin. Surprisingly, Cr2-/- mice generate significant Ab responses and germinal center (GC) reactions to low doses of this Ag in alum, although the magnitude of their responses...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10779753
DOI: 10.4049/jimmunol.164.9.4522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence.PMID 10779753Read ↗

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