Article
Conditional depletion of mast cells has no impact on the severity of experimental epidermolysis bullosa acquisita.
European journal of immunology - 1 May 2015
Kasprick Anika, Yu Xinhua, Scholten Julia, Hartmann Karin, Pas Hendri H, Zillikens Detlef, Ludwig Ralf J, Petersen Frank
Abstract excerpt
The role of mast cells (MCs) in autoimmunity is the matter of an intensive scientific debate. Based on observations in different MC-deficient mouse strains, MCs are considered as fundamental players in autoimmune diseases. However, most recent data suggest that the outcome of such diseases is strongly affected by the individual mouse strain used. By the use of two c-Kit mutant MC-deficient mouse strains and one...
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