Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Humoral Response Suppression Observed with CD23 Transgenics

1 Jul 1999

Abstract excerpt

CD23, also known as the low affinity IgE receptor (FcepsilonRII), has been hypothesized to have a role in IgE regulation. A new CD23 transgenic mouse was generated using the MHC class I promoter and IgH enhancer to further test the hypothesis that CD23 plays a role in the down-regulation of IgE. Study of three founder lines by FACS showed overexpression to varying extents on both B and T lymphocytes. No...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10384119
DOI: 10.4049/jimmunol.163.1.217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Humoral Response Suppression Observed with CD23 TransgenicsPMID 10384119Read ↗

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.Semantic proximity Read ↗

Uncoupling of natural IgE production and CD23 surface expression levels.Semantic proximity Read ↗

129/SvJ mice have mutated CD23 and hyper IgE.Semantic proximity Read ↗

Hyper IgE in New Zealand black mice due to a dominant-negative CD23 mutation.Semantic proximity Read ↗

CD23: an overlooked regulator of allergic disease.Semantic proximity Read ↗

Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in MiceSemantic proximity Read ↗

A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus ErythematosusSemantic proximity Read ↗

IL-13 overexpression predisposes to anaphylaxis following antigen sensitization.Semantic proximity Read ↗

Frontline Science: Superior mouse eosinophil depletion in vivo targeting transgenic Siglec-8 instead of endogenous Siglec-F: Mechanisms and pitfalls.Semantic proximity Read ↗

Impaired antibody responses in H-2Ab mice.Semantic proximity Read ↗

Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthmaSemantic proximity Read ↗

Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.