Article
Hyper-reactive cloned mice generated by direct nuclear transfer of antigen-specific CD4+ T cells.
EMBO reports - 1 Jun 2017
Kaminuma Osamu, Katayama Kazufumi, Inoue Kimiko, Saeki Mayumi, Nishimura Tomoe, Kitamura Noriko, Shimo Yusuke, Tofukuji Soichi, Ishida Satoru, Ogonuki Narumi, Kamimura Satoshi, Oikawa Mami, Katoh Shigeki, Mori Akio, Shichijo Michitaka, Hiroi Takachika, Ogura Atsuo
Abstract excerpt
T-cell receptor (TCR)-transgenic mice have been employed for evaluating antigen-response mechanisms, but their non-endogenous TCR might induce immune response differently than the physiologically expressed TCR Nuclear transfer cloning produces animals that retain the donor genotype in all tissues including germline and immune systems. Taking advantage of this feature, we generated cloned mice that carry...
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