Article
Evidence for regulation of cartilage differentiation by the homeobox gene Hoxc-8.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Yueh Y G, Gardner D P, Kappen C
Abstract excerpt
Homeobox genes of the Hox class are required for proper patterning of skeletal elements, but how they regulate the differentiation of specific tissues is unclear. We show here that overexpression of a Hoxc-8 transgene causes cartilage defects whose severity depends on transgene dosage. The abnorm...
Topics
- Animals
- Cartilage
- Cell Differentiation
- Chondrocytes
- Crosses, Genetic
- Exostoses, Multiple Hereditary
- Female
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Genotype
- Homeodomain Proteins
- Humans
- Male
- Mice
- Mice, Transgenic
- Models, Biological
- Phenotype
- Pregnancy