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Article

Fate of growth plate hypertrophic chondrocytes: Death or lineage extension?

1 Feb 2015

Abstract excerpt

The vertebrate growth plate is an essential tissue that mediates and controls bone growth. It forms through a multistep differentiation process in which chondrocytes differentiate, proliferate, stop dividing and undergo hypertrophy, which entails a 20-fold increase in size. Hypertrophic chondrocytes are specialized cells considered to be the end state of the chondrocyte differentiation pathway, and are essential...

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PMID: 25714187
DOI: 10.1111/dgd.12203

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