Foxd3 is an essential Nodal-dependent regulator of zebrafish dorsal mesoderm development.

Abstract excerpt

Establishment of the embryonic mesoderm is dependent on integration of multiple signaling and transcriptional inputs. We report that the transcriptional regulator Foxd3 is essential for dorsal mesoderm formation in zebrafish, and that this function is dependent on the Nodal pathway. Foxd3 gain-of-function results in expanded dorsal mesodermal gene expression, including the Nodal-related gene cyclops, and body...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Embryo, Nonmammalian
• Share to Forkhead Transcription Factors
• Share to Gene Expression Regulation, Developmental