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Article

The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities.

Development (Cambridge, England) - 1 Aug 2008

Tian Jing, Andrée Birgit, Jones C Michael, Sampath Karuna

Abstract excerpt

Nodal proteins are secreted signaling factors of the transforming growth factor beta (TGFbeta) family with essential roles in embryonic development in vertebrates. Mutations affecting the Nodal factors have severe consequences in mammals and fish. Furthermore, increased Nodal levels have been associated with melanoma tumor progression. Like other TGFbeta-related proteins, Nodal factors consist of a pro-domain and...

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Identifiers

PMID: 18579681
DOI: 10.1242/dev.019794

Genes

NODAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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