Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine.

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Article

Analysis of yeast DNA topoisomerase II mutants resistant to the antitumor drug amsacrine.

Cancer research - 1 Apr 1994

Wasserman R A, Wang J C

Abstract excerpt

Site-directed mutagenesis of regions within a plasmid-borne yeast TOP2 gene encoding DNA topoisomerase II and hydroxylamine mutagenesis of the entire plasmid were carried out, and the mutagenized plasmid DNA pools were used separately to transform yeast with a temperature-sensitive top2-4 mutatio...

Topics

Alleles
Amino Acid Sequence
Amsacrine
Base Sequence
Chromosomes, Fungal
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Genes, Fungal
Genetic Complementation Test
Hydroxylamine
Hydroxylamines
Molecular Sequence Data
Mutagenesis
Mutagenesis, Site-Directed
Oligodeoxyribonucleotides
Plasmids
Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 8137294

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8137294-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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