Article
Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.
Nature medicine - 1 Aug 1998
Bajou K, Noël A, Gerard R D, Masson V, Brunner N, Holst-Hansen C, Skobe M, Fusenig N E, Carmeliet P, Collen D, Foidart J M
Abstract excerpt
Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been corre...
Topics
- Adenoviridae
- Animals
- Cell Transformation, Neoplastic
- Cells, Cultured
- Disease Progression
- Female
- Genetic Vectors
- Genotype
- Humans
- Keratinocytes
- Male
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neovascularization, Pathologic