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Article

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization.

Nature medicine - 1 Aug 1998

Bajou K, Noël A, Gerard R D, Masson V, Brunner N, Holst-Hansen C, Skobe M, Fusenig N E, Carmeliet P, Collen D, Foidart J M

Abstract excerpt

Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been correlated with a poor prognosis for some cancers. We report here that deficient PAI1 expression in host mice prevented...

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PMID: 9701244
DOI: 10.1038/nm0898-923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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