Article
Plasminogen activator inhibitor type-1 mutants regulate angiogenesis of human umbilical and lung vascular endothelial cells.
Oncology reports - 1 Dec 2004
Chorostowska-Wynimko Joanna, Swiercz Rafal, Skrzypczak-Jankun Ewa, Selman Steven H, Jankun Jerzy
Abstract excerpt
Plasminogen activator inhibitor type-1 (PAI-1) is considered one of the key regulators of tumor invasion, metastasis, as well as cancer-related angiogenesis. The literature suggests that PAI-1 plays a dual role in these processes because it inhibits plasmin-originated proteolysis and binds to vitronectin or integrins. Stimulation or inhibition of angiogenesis largely depends on which of these elements PAI-1...
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