Article
Role of plasminogen activator inhibitor-1 in urokinase's paradoxical in vivo tumor suppressing or promoting effects.
Molecular cancer research : MCR - 1 Oct 2012
Jing Yuqi, Kovacs Krisztina, Kurisetty Vittal, Jiang Zhijie, Tsinoremas Nick, Merchan Jaime R
Abstract excerpt
Tumor proteases and inhibitors have been associated with paradoxical effects on tumor progression in preclinical and clinical settings. We previously reported that urokinase (uPA) overexpression delays tumor progression in mammary cancer. This study aimed to determine the role of plasminogen activator inhibitor-1 (PAI-1) on uPA's paradoxical in vivo effects. Using syngeneic murine models, we found that stable uPA...
Topics
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Clone Cells
- Disease Models, Animal
- Disease Progression
- Down-Regulation
- Female
- Gene Expression Regulation, Neoplastic
- Immunohistochemistry
- Mice
- Mice, Inbred BALB C
- Neoplasm Metastasis