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Article

Transgenic overexpression of a stable Plasminogen Activator Inhibitor-1 variant.

Thrombosis research - 1 Mar 2009

Fahim Abigail T, Wang He, Feng Jining, Ginsburg David

Abstract excerpt

INTRODUCTION: Plasminogen Activator Inhibitor-1 (PAI-1) is a member of the Serine Protease Inhibitor (SERPIN) gene family and a key regulator of fibrinolysis. PAI-1 is unique among SERPINs in its spontaneous transition to a latent, inactive state, with a half-life of approximately 2 hours under physiologic conditions. The biologic importance of the PAI-1 transition to latency is unknown. This study aimed to...

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Identifiers

PMID: 18774162
DOI: 10.1016/j.thromres.2008.07.004
PMCID: PMC2670886

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Source receipt: pubmed, retrieved 7 Sept 2026.

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