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Article

Protease activity of urokinase and tumor progression in a syngeneic mammary cancer model.

Journal of the National Cancer Institute - 7 Jun 2006

Merchan Jaime R, Tang Jian, Hu Guang, Lin Yanfeng, Mutter Walter, Tong Caili, Karumanchi S Ananth, Russell Stephen J, Sukhatme Vikas P

Abstract excerpt

BACKGROUND: We and others have previously shown that plasminogen activators generate endogenous angiogenesis inhibitors and induce antiangiogenic activity. Here we assessed the effects of plasminogen activator overexpression on tumor progression in a syngeneic mammary cancer model. METHODS: Genes encoding murine tissue plasminogen activator (tPA), urokinase (uPA), and vector controls were stably transfected into...

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PMID: 16757700
DOI: 10.1093/jnci/djj208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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