Article
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.
Cancer research - 15 Jan 2001
Frandsen T L, Holst-Hansen C, Nielsen B S, Christensen I J, Nyengaard J R, Carmeliet P, Brünner N
Abstract excerpt
Several studies have indicated an interaction between tumor cells and infiltrating stromal cells regarding the urokinase plasminogen activation (uPA) system. By developing combined uPA gene-disrupted and immunodeficient mice, we have studied the role of stromal uPA for the growth of the MDA-MB-43...
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