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Article

Prognostic significance of p53 overexpression in primary breast cancer; a novel luminometric immunoassay applicable on steroid receptor cytosols.

British journal of cancer - 1 May 1995

Borg A, Lennerstrand J, Stenmark-Askmalm M, Fernö M, Brisfors A, Ohrvik A, Stål O, Killander D, Lane D, Brundell J

Abstract excerpt

A novel quantitative luminometric immunoassay (LIA) has been developed for the measurement of wild-type and mutant p53 protein in extracts from breast tumour tissue. The LIA was found to yield reliable estimates of p53 expression in cytosol samples routinely prepared for steroid receptor analysis as compared with results obtained with immunohistochemical analysis. The LIA was evaluated on 205 primary breast...

Topics

Breast Neoplasms
Cytosol
Evaluation Studies as Topic
Female
Gene Expression
Genes, p53
Humans
Immunohistochemistry
Luminescent Measurements
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Receptors, Estrogen

Receptors, Progesterone

Retrospective Studies

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 7734292
DOI: 10.1038/bjc.1995.195
PMCID: PMC2033772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7734292-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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