The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer.

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Article

The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer.

Cancer research - 1 Mar 2001

Linderholm B K, Lindahl T, Holmberg L, Klaar S, Lennerstrand J, Henriksson R, Bergh J

Abstract excerpt

Wild-type p53 protein has been shown to inhibit angiogenesis through thrombospondin in the preclinical setting. Here, we determined the associations between the expression of the angiogenic factor vascular endothelial growth factor (VEGF) and the p53 status, including different mutation sites and types, in primary breast cancer. Cytosols from 224 primary breast cancer patients were analyzed with an enzyme...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Disease-Free Survival
Endothelial Growth Factors
Female
Follow-Up Studies
Genes, p53
Humans
Immunohistochemistry
Lymphokines
Middle Aged
Multivariate Analysis
Mutation

Source

Open in PubMed

Identifiers

PMID: 11280795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Sequence Analysis, DNA

Survival Rate

Vascular Endothelial Growth Factor A