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Article

Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception.

Neuron - 1 Jul 1998

Yang Z, Emerson M, Su H S, Sehgal A

Abstract excerpt

The period (per) and timeless (tim) genes are required for circadian behavioral rhythms in Drosophila. The current model for how these rhythms entrain to light is based upon the light induced decrease in timeless protein (TIM) levels. We show here that the TIM response to light correlates with the effect of light on the behavioral rhythm. To identify components of the entrainment pathway, we also assayed the TIM...

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PMID: 9697865
DOI: 10.1016/s0896-6273(00)80528-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception.PMID 9697865Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

Role of molecular oscillations in generating behavioral rhythms in Drosophila.Semantic proximity Read ↗

Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila.Semantic proximity Read ↗

Block in nuclear localization of period protein by a second clock mutation, timeless.Semantic proximity Read ↗

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

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