Article
Block in nuclear localization of period protein by a second clock mutation, timeless.
Science (New York, N.Y.) - 18 Mar 1994
Vosshall L B, Price J L, Sehgal A, Saez L, Young M W
Abstract excerpt
In wild-type Drosophila, the period protein (PER) is found in nuclei of the eyes and brain, and PER immunoreactivity oscillates with a circadian rhythm. The studies described here indicate that the nuclear localization of PER is blocked by timeless (tim), a second chromosome mutation that, like p...
Topics
- Animals
- Biological Clocks
- Cell Nucleus
- Circadian Rhythm
- Cytoplasm
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression
- Genes, Insect
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Phenotype
- Recombinant Fusion Proteins