Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.

Neuron - 1 May 2000

Rothenfluh A, Young M W, Saez L

Abstract excerpt

The mutation timeless(UL) generates 33 hr rhythms, prolonged nuclear localization of PERIOD/TIMELESS(UL) protein complexes, and protracted derepression of period (per) and timeless (tim) transcription. Light-induced elimination of TIM(UL) from nuclear PER/TIM(UL) complexes gives strong downregulation of per and tim expression. Thus, in the absence of TIM, nuclear PER can function as a potent negative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Clocks
Share to Cell Nucleus
Share to Circadian Rhythm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila

Share to Drosophila Proteins

Share to Gene Deletion

Share to Insect Proteins

Share to Period Circadian Proteins

Source

Identifiers

PMID: 10839368
DOI: 10.1016/s0896-6273(00)81182-4

Genes

TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.PMID 10839368Read ↗

Block in nuclear localization of period protein by a second clock mutation, timeless.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

Regulation of the cycling of timeless (tim) RNA.Semantic proximity Read ↗

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.Semantic proximity Read ↗

Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.