Article
Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005
Collins Ben H, Dissel Stephane, Gaten Edward, Rosato Ezio, Kyriacou Charalambos P
Abstract excerpt
The Drosophila melanogaster circadian clock is generated by interlocked feedback loops, and null mutations in core genes such as period and timeless generate behavioral arrhythmicity in constant darkness. In light-dark cycles, the elevation in locomotor activity that usually anticipates the light on or off signals is severely compromised in these mutants. Light transduction pathways mediated by the rhodopsins and...
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