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Article

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.

Journal of biological rhythms - 1 Aug 2006

Chen Wen-Feng, Majercak John, Edery Isaac

Abstract excerpt

Numerous lines of evidence indicate that the initial photoresponse of the circadian clock in Drosophila melanogaster is the light-induced degradation of TIMELESS (TIM). This posttranslational mechanism is in sharp contrast to the well-characterized pacemakers in mammals and Neurospora, where light evokes rapid changes in the transcriptional profiles of 1 or more clock genes. The authors show that light has novel...

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Source

Identifiers

PMID: 16864646
DOI: 10.1177/0748730406289306

Genes

CLOCK
TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.PMID 16864646Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

Regulation of the cycling of timeless (tim) RNA.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

A natural <i>timeless</i> polymorphism allowing circadian clock synchronization in ‘white nights’Semantic proximity Read ↗

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

Light-dependent sequestration of TIMELESS by CRYPTOCHROME.Semantic proximity Read ↗

CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.Semantic proximity Read ↗

Exquisite light sensitivity of Drosophila melanogaster cryptochrome.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks.Semantic proximity Read ↗

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