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Article

Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster.

Neuron - 1 Jul 1998

Suri V, Qian Z, Hall J C, Rosbash M

Abstract excerpt

Light is a major environmental signal for the entrainment of circadian rhythms. In Drosophila melanogaster, recent experiments suggest that photic information is transduced to the clock through the timeless gene product, TIM. We provide genetic and spectral evidence supporting the relevance of TIM light responses to clock resetting. A missense mutant TIM, TIM-SL, exhibits greater sensitivity to light in both TIM...

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PMID: 9697866
DOI: 10.1016/s0896-6273(00)80529-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster.PMID 9697866Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

Exquisite light sensitivity of Drosophila melanogaster cryptochrome.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception.Semantic proximity Read ↗

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila.Semantic proximity Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

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