Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.

doi:10.1038/28860

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Article

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.

Nature - 30 Jul 1998

Klenerman P, Zinkernagel R M

Abstract excerpt

Some viruses, including human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in humans, and lymphocytic choriomeningitis virus (LCMV) in mice, are initially controlled by cytotoxic T lymphocytes (CTLs), but may subsequently escape through mutation of the relevant T-cell epitope. Some of...

Topics

Animals
Epitopes, T-Lymphocyte
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred DBA
Models, Immunological
Mutation
T-Lymphocytes, Cytotoxic

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